Comorbidities Are Usually Associated With SpA

Compared to the general population, spondyloarthritis (SpA) disorders are commonly associated with comorbidities that can add to the burden of disease by impacting disease activity, work disability, morbidity, and mortality.1-4

Common SpA-associated comorbidities1-3:

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Shared Inflammatory Pathways

SpA and its associated comorbidities may have an underlying shared pathophysiology.

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A Bidirectional Relationship

Comorbidities associated with SpA have an impact on disease activity and can influence treatment decisions.1

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References:

1. Bosch P et al. Best Pract Res Clin Rheumatol. 2023; 101857. 2. Hou X et al. Int J Rheum Dis. 2023;26(7):1222-1224. 3. López-Medina C, Molto A. RMD Open. 2020;6(2):e001135. 4. Moltó A, Nikiphorou E. Front Med (Lausanne). 2018;5:62. 5. Ferrucci L et al. Nat Rev Cardiol. 2018;15(9):505-522. 6. Tillet W et al. Rheumatology (Oxford). 2015;54(1):157-162. 7. Raes Dl et al. BMC Public Health. 2007;7:269. 8. Salive ME. Epidemiol Rev. 2013;35:75-83.
9. Stenholm S et al. J Gerontol A Biol Sci Med Sci. 2015;70(3):332-338. 10. Fragoulis GE et al. J Rheumatol. 2022;49(10):1085-1091. 11. Li L et al. J Clin Rheumatol. 2015;21(8):405-410. 12. Ogdie A et al. Ann Rheum Dis. 2015;74(2):326-332. 13. Li PH et al. J Clin Rheumatol. 2019;19(1):1-8. 14. Lee TH et al. Ther Adv Musculoskelet Dis. 2022;14:1759720X221100301. 15. Frede N et al. RMD Open. 2023;9:e002912. 16. Salari N et al. Adv Rheumatol. 2023;63:33. 17. Chaudhary H et al. Arthritis Care Res. 20223;75(5):1052-1065.